The effect of smoking on Alzheimer's disease Lead Investigator: Jonathan Spiegel Institution : NYU Center for Brain Health E-Mail : jonathan_spiegel@brown.edu Proposal ID : 923 Proposal Description: The project aims to look at neuropathological differences between smokers and non-smokers. While past work has shown that smoking is robustly associated with greater rates of cognitive decline and clinical diagnoses of dementia, the small bit of work that has been done looking post-mortem sees lower rates of Alzheimer's associated proteinopathies.